Tom Six's The Human Centipede (First Sequence) is an insane biological horror film that enthusiastically explores territory that few filmmakers dare to tread. In The Human Centipede, Dr. Heiter (Dieter Laser) is a leering, sepulchral surgeon from Germany whose specialty is separating Siamese twins. Dr. Heiter decides to evolve his craft by sewing together living beings together at the "mucous-cutaneous zone" (guess) in order to create Siamese triplets with a single digestive system. After his experiment in creating a three-segment rottweiler ("a beautiful three-hound construction") fails, Dr. Heiter tries again, shifting his attention to humans. First, a trucker is stolen away while relieving himself on the side of the road, Next, two clueless party girls who come knocking on Dr. Heiter's door after getting lost in the German forest get pulled into the experiment. After erasing the trucker from the picture, the doctor finds another victim: a crazed Japanese man wandering around Germany. The doctor concludes the initial phase of his experiment by splicing together the two girls and the Japanese man. At this stage, the film really goes berserk as Dr. Heiter attempts to impose his personal brand of order and discipline on an increasingly out-of-control situation.